William S. Hlavacek

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Biographical Sketch

 

NAME POSITION TITLE
HLAVACEK, William S. Technical Staff Member

 

EDUCATION

INSTITUTION DEGREE YEAR FIELD OF STUDY
University of Arkansas B.S. 1989 Chem. Eng.
University of Michigan M.S. 1991 Chem. Eng.
University of Michigan Ph.D. 1996 Chem. Eng.
Los Alamos National Laboratory Postdoc 1996-2000 Theor. Immunol.

 

PROFESSIONAL EXPERIENCE

1989-1996 Graduate Research Assistant, Department of Chemical Engineering, University of Michigan, Ann Arbor, MI
1996-2000 Postdoctoral Research Associate, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos NM
2000-2004 Limited-term Technical Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM
2003-present Adjunct Assistant Professor, Department of Biology, University of New Mexico, Albuquerque, NM
2004-present Technical Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM
2006-2007 Acting Deputy Director, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM
2007-present Research Associate Professor, Department of Biology, University of New Mexico, Albuquerque, NM
2007-present Executive Committee, Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM
2007-present Editorial Board, Mathematical Biology Section, Biology Direct

 

HONORS & AWARDS

  • 1986-1989, Kodak Scholar
  • 1990-1993, Du Pont Research Fellow
  • 1992-1993, Du Pont Teaching Fellow

 

SELECTED PUBLICATIONS

  • W. S. Hlavacek and M. A. Savageau (1996) Rules for coupled expression of regulator and effector genes in inducible circuits. J. Mol. Biol. 255, 121-139.
  • W. S. Hlavacek, R. G. Posner and A. S. Perelson (1999) Steric effects on multivalent ligand-receptor binding: exclusion of ligand sites by bound cell surface receptors. Biophys. J. 76, 2421-2431.
  • W. S. Hlavacek, C. Wofsy and A. S. Perelson (1999) Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis. Proc. Natl. Acad. Sci. USA 96, 14681-14686.
  • W. S. Hlavacek, N. I. Stilianakis, D. W. Notermans, S. A. Danner and A. S. Perelson (2000) Influence of follicular dendritic cells on decay of HIV during antiretroviral therapy. Proc. Natl. Acad. Sci. USA 97, 10966-10971.
  • W. S. Hlavacek, A. Redondo, H. Metzger, C. Wofsy and B. Goldstein (2001) Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc. Natl. Acad. Sci. USA 98, 7295-7300.
  • J. R. Faeder, W. S. Hlavacek, I. Reischl, M. L. Blinov, H. Metzger, A. Redondo, C. Wofsy and B. Goldstein (2003) Investigation of early events in FceRI-mediated signaling using a detailed mathematical model. J. Immunol. 170, 3769-3781.
  • W. S. Hlavacek, J. R. Faeder, M. L. Blinov, A. S. Perelson and B. Goldstein (2003) The complexity of complexes in signal transduction. Biotechnol. Bioeng. 84, 783-794.
  • M. E. Wall, W. S. Hlavacek and M. A. Savageau (2004) Design of gene circuits: lessons from bacteria. Nat. Rev. Genet. 5, 34-42.
  • B. Goldstein, J. R. Faeder and W. S. Hlavacek (2004) Mathematical and computational models of immune-receptor signalling. Nat. Rev. Immunol. 4, 445-456.
  • M. L. Blinov, J. R. Faeder, B. Goldstein and W. S. Hlavacek (2004) BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains. Bioinformatics 20, 3289-3291.

 

GRANTS & CONTRACTS

  • NIH/NIAID, Immune system modeling/HIV, Co-PI
  • DOE/Genomics:GTL, Metabolic functional analysis of bacterial genomes , Co-investigator
  • NIH/NCRR, Theoretical and evolutionary immunology: the search for fundamental principles. Supports the Center for Evolutionary and Theoretical Immunology. PI of the CETI project "Mathematical modeling of signal transduction by a TIR receptor"
  • NIH/NIGMS, System-wide study of transcriptional control of metabolism, PI
  • NIH/NIGMS, Computational tools for rule-based modeling of biochemical systems, PI
  • NIH/NCI, Differential metabolic network analysis of tumor progression, Co-investigator