This is the home page of the Sanbonmatsu ribosome team in the Theoretical Biology and Biophysics Group of the Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico. The team uses high performance computing to understand the universal mechanism by which ribosomes read genetic information and synthesize proteins in all organisms. The team aims to contribute to the understanding of the action and resistance mechansims of protein synthesis antibiotics.

How does the ribosome decode genetic information? How do antibiotics affect this process? How can we design more effective antibiotics with fewer side effects?

To address these questions, we are performing large-scale molecular dynamics simulations of the ribosome, allowing us to image the ribosome in atomic detail as it decodes genetic information.